*Program is subject to change
As speakers and abstract presenters confirm more details will become available.

Pre Arrival Days

8:00 AM – 8:30 PM                           Registration

Vide Foyer

11:30 AM – 1:00 PM                            Lunch (on own)

PRE–CONFERENCE WORKSHOPS

Pre–Registration Required. Ticketed sessions.

 

12:00 PM – 4:00 PM                            Pre–Conference Workshop: From Bench to Boardroom: Commercializing your RM Product or Therapy

Osgoode Ballroom

Description: The global regenerative medicine market was valued at US$23.8 billion (2018), and it is anticipated to grow to US$151 billion by 2026 with an annual growth rate of 26.1 per cent. Cell and gene therapies are being approved and reimbursed. It’s an exciting time to be an entrepreneur in this field. Join Centre for Commercialization of Regenerative Medicine (CCRM) experts and special guests for a brief but helpful overview of the main issues to consider in your entrepreneurial journey from innovator to business leader. A taught case study will cover some of the main points to consider when taking your product or therapy to the marketplace. The afternoon will culminate with a thought–provoking and insightful keynote address from a well–respected leader in the field. You will walk away from this workshop feeling more knowledgeable, confident and inspired.

Workshop Chair: Michael May, CCRM

Program:
12:00 PM – 1:00 PM                   CCRM sponsored lunch and case study presentation

1:00 PM – 1:15 PM                    Welcome and Introduction, Dr. Michael May

1:15 PM – 2:45 PM                    Presentations, Delivered by CCRM experts:

Introduction to Technology Transfer & Intellectual Property
Vishan Sivagnanam, Commercialization Manager

Manufacturing and Process Development
Dr. Cheryl Birmingham, Director, Process & Analytical Development

Regulatory Affairs in Regenerative Medicine: An Overview
Sanyukta Kher, Regulatory Affairs Consultant

Considerations for Scaling Regenerative Medicine Companies
Dr. Robin Quirk, Vice President, Technology Sourcing & Venture Development

Financing for Early Start-ups – Addressing the Gap!
Dr. Cynthia Lavoie, President and Chief Investment Officer, CCRM Enterprises

Building a Compelling Investor Pitch Deck for Life Science Start-Ups
Matthew Mistry, Senior Associate and Head of CGT Projects, CCRM Enterprises

2:45 PM – 3:15 PM                    Case study discussion with facilitators

3:15 PM – 4:00 PM                    Keynote Presentation: Bioprinting Tissue Therapeutics to Transform How We Treat Disease
Tamer Mohamed, Chief Executive Officer, Aspect Biosystems

 

 

1:00 PM – 4:00 PM                    Pre–Conference Workshop: 3D Bioprinting: Principles and Strategies for Tissue Engineering and Regenerative Medicine

Grand Ballroom Centre

Description: Stem Cell Network is pleased to host the “3D Bioprinting: Principles and Strategies for Tissue Engineering and Regenerative Medicine” as part of the TERMIS–AM meeting in partnership with Aspect Biosystems and FluidForm TM Inc. Tissue engineering holds the potential to transform drug discovery and clinical practice for regenerative medicine. While the creation of whole organs is a long–term goal, 3D bioprinted tissues already show promise in improving patient care as implantable therapeutic tissues and as more predictive models in drug development.

A multitude of strategies have arisen to recapitulate the structural and functional complexity of human tissues using additive manufacturing methods. A common challenge in the field is that biomaterials that preserve cell viability and promote function may not meet the structural and mechanical requirements of the application. This workshop focuses on strategies to overcome this and other challenges in tissue engineering using extrusion–based bioprinting methods.

The workshop will feature expert speakers working in the field and a panel discussion with industry leaders on the commercialization and translation of 3D bioprinting. The talks will be followed by technology demonstrations of Aspect Biosystems’ microfluidic 3D bioprinting technology and FluidForm’s FRESH printing platform. Both technologies offer strategies for creating complex tissue structures while promoting tissue function.

Workshop Chair: Ellie Arnold, Stem Cell Network

Program:
1:00 PM – 1:10 PM                    Introduction

1:10 PM – 1:40 PM                    Stephanie Willerth, University of Victoria

1:40 PM – 2:10 PM                    Brenda Ogle, University of Minnesota

2:10 PM – 2:15 PM                    5 minute break

2:15 PM – 3:05 PM                    Panel Discussion on Commercialization and Translation

3:05 PM – 3:10 PM                    5 minute break

3:10 PM – 4:00 PM                    Demo stations from Aspect Biosystems and FluidForm

4:00 PM                                    Wrap up and close

 

1:00 PM – 4:00 PM                    Pre–Conference Workshop: Functional Biomaterials in Cardiopulmonary Research: A Road Map from Design to Clinical Translation

Grand Ballroom West

Description: This workshop, being organized by Dr. Emilio I. Alarcón at the University of Ottawa Heart Institute & Faculty of Medicine, University of Ottawa, aims to review the current state of the art of biomaterials for cardiac research. We will cover aspects from the material design, fabrication, in vitro & in vivo testing to the preclinical testing & regulatory considerations for use in humans. Participants in the workshop will be part of a dynamic afternoon with speakers from different backgrounds working in the field spanning from chemistry, physics, cell biology, and clinical research in cardiac health.

Workshop Chair: Dr. Emilio I. Alarcón, University of Ottawa

Speakers:
Dr Edmond W. K. Young, University of Toronto
Dr Golnaz Karoubi, University of Toronto; University Health Network
Dr Houman Savoji, Université de Montréal
Dr Duncan Stewart, University of Ottawa; The Ottawa Hospital
Dr Michael Laflamme, University Health Network; University of Toronto

Program:
Part I
1:00 PM – 1:05 PM                    Opening Remarks

1:05 PM – 1:20 PM                    Peptides vs Proteins for the Development of Biomaterials for Cardiopulmonary Repair

1:20 PM – 1:40 PM                    Microfluidics and Bioprinting as the Next Frontier of Biomaterials for Cardiopulmonary Repair

1:40 PM – 2:20 PM                    Lung on A Chip: Accelerating Clinical Translation

2:20 PM – 2:55 PM                    Q&A For Part I

2:55 PM – 3:15 PM                    Coffee Break & Networking

Part II

2:55 PM – 3:15 PM                    Cell–Based Therapeutics for Cardiopulmonary Repair

3:15 PM – 3:35 PM                    Biomaterials–Based Therapies for Heart and Lung Repair

3:35 PM – 3:55                          Q&A for Part II

3:55 PM – 4:00 PM                    Closing Remarks

 

1:00 PM – 4:00 PM                    Pre–Conference Workshop: Entrepreneurship
Grand Ballroom East

Description:
NSERC CREATE Training Program in Organ–on–a–Chip & Entrepreneurship (TOeP) is organizing a pre–conference workshop geared towards inspiring trainees to engage into a process of taking their discovery out of the lab and into the real world.

Uniquely, our workshop speakers were all (or still are) trainees who haven commercialized the discoveries from their PhD or Post–doctoral training through a start–up company. They were instrumental in growing these companies and have valuable lessons to share to facilitate the journey.

At the end of this workshop, you will be able to: understand how to identify the novel components of your work, improve problem–based design in tissue engineering and regenerative medicine, understand the steps toward commercialization of devices and cell based therapeutics and what elements to include in a successful pitch.

NSERC CREATE TOeP Training program will reimburse the workshop registration fee for the first 30 trainees who register. Reimbursement forms will be available at the workshop.

Workshop Chair: Milica Radisic, University of Toronto

Program:

1:00 PM – 1:20 PM                    Introduction to the Goals of the Workshop
Milica Radisic, Professor and Canada Research Chair (Tier 1) in Organ–on–a–Chip Engineering, University of Toronto; Senior Scientist, Toronto General Research Institute; Director, NSERC CREATE Training Program in Organ–on–a–Chip Engineering and entrepreneurship.

1:20 PM – 1:40 PM                    From an Idea to a Successful Company – the Story of Rheolution
Anis Hadjenni, CEO and Co–founder, Rheolution Inc,

1:40 PM – 2:00 PM                    Assessing the Novelty of your Idea – the Story of Ripple
Wendy Neimark, Co–founder and Chief Technology Officer, Ripple Therapeutics

2:00 PM – 2:20 PM                    Developing a Pitch and Setting your Idea for Successful Fundraising 
Milica Vukmirovic, Director of External Programs & Partnerships, Precision Medicine Initiative, PRiME, University of Toronto

2:20 PM – 3:00 PM                    Networking break

3:00 PM – 3:20 PM                    Working to Grow your Organ–on–a–chip Startup           
Sepand Bafti, Director of Biological Science at Norti

3:20 PM – 3:40 PM                    Trainee Perspective – Starting a Company During your PhD
Dawn Lin, PhD Candidate at McMaster University & Co–founder Organo–Biotech,

3:40 PM – 4:00 PM                    PI Perspective on Starting a Company from the Lab
Mohsen Akbari, Associate Professor, University of Victoria

 

SCIENTIFIC PROGRAM

 

1:00 PM – 3:00 PM                          TERMIS–AM Council Meeting (Council Members Only)
Simcoe/Dufferin, 2nd Floor

Opening Program
Grand Ballroom Centre & West

4:00 PM – 4:15 PM                              Land Acknowledgement and Prayer

4:15 PM – 4:25 PM                           TERMIS President and TERMIS–AM Chair Welcome

4:25 PM – 4:30 PM                            Welcome from the TERMIS–AM 2022 Conference Co–Chairs

4:30 PM – 5:30 PM                           Fireside Chat on Commercialization with TERMIS–AM Awardees

Moderator: Michael May
Panelists:
Michael Laflamme, MD, PhD
Gordana Vunjak–Novaković, PhD 
Guillermo Ameer, ScD

5:30 PM – 6:30 PM                            Opening Plenary Symposium 1: Freda Miller, PhD
                                                            Building and Repairing the Nervous System with Stem Cells
                                                                Keynote Sponsored by: CCRM and Stem Cell Network, and Medicine by Design (MbD)

6:30 PM – 8:30 PM                              Exhibit Viewing / Welcome Reception / Poster Session 1
Sheraton Hall A – F                       
Sponsored by CCRM and Stem Cell Network

6:00 AM – 7:30 PM                           Registration

Vide Foyer 

7:00 AM – 8:00 AM                     Cook Biotech Sponsored Breakfast Symposia – “MetamorphoSIS: The Potential of the Extracellular Matrix Scaffold”

Civic South
For more than 25 years, Cook Biotech has partnered with academic groups to supply clinical–grade ECM scaffolds that can translate your cell therapy innovation from the bench to the bedside. In this breakfast symposium, learn how Cook Biotech can be your trusted partner to bring life–improving solutions to patients. Our team will be on hand to talk with you about collaboration. Please join us for breakfast (limited to 50 attendees).

7:00 AM – 8:00 AM                    TERMIS–AM TWIGs Chairs Meeting
Simcoe/Dufferin

8:00 AM – 9:00 AM                    Plenary Symposium 2: Charles Gersbach, PhD
Genome and Epigenome Editing for Gene Therapy and Cell Programming

Grand Ballroom Centre & West

9:00 AM – 9:30 AM                    Award Presentation (colored box)
TERMIS–AM Senior Scientist Award: Eben Alsberg, PhD
TERMIS–AM Commercialization/Innovation Award: Guillermo Ameer, ScD

Grand Ballroom Centre & West

9:30 AM – 10:00 AM                  Coffee Break in Exhibit Hall
Sheraton Hall A – F

9:30 AM – 10:00 AM                  TERMIS–AM Membership Business Meeting
Osgoode Ballroom

10:00 AM – 11:30 AM                Scientific Concurrent Sessions 1

Grand Ballroom Centre                Session 1: Skin, Wound Healing, and Inflammation Part 1

Session Chairs: Lucie Germain and Véronique Moulin
SYIS Co–Chair: Daniel Gironda

Keynote Speaker:                            Novel Regulators of Stress Response and Innate Immunity in Skin
10:00 AM – 10:30 AM                    
Pierre A. Coulombe

ORAL PRESENTATIONS:

10:30 AM – 10:45 AM                    1

Ex Vivo Gene Therapy Of Skin Cells And Autologous Bilayered Skin Substitutes As A Potential Treatment For Recessive Dystrophic Epidermolysis Bullosa Skin Wounds

  1. A. Barbier1, A. Dakiw Piaceski1, A. Morissette1, A. Larose1, A. Cartier1, S. Villeneuve1, D. Larouche1, K. Ghani2, E. Pope3, M. Caruso2, L. Germain1;
    1Département de chirurgie, Centre de Recherche en organogénèse expérimentale de l’Université Laval / LOEX, Québec, QC, CANADA, 2Centre de Recherche sur le cancer de l’Université Laval, Québec, QC, CANADA, 3Hospital for Sick Children and University of Toronto, Toronto, ON, CANADA.

10:45 AM – 11:00 AM                     2

Building The Skin–specific Vascular Plexus And Appendages With Perfusion Capabilities

  1. Pappalardo1, D. Alvarez Cespedes1, E. Y. Jeon1, L. Sorrells2, H. E. Abaci1;
    1Department of Dermatology, Columbia University, New York, NY, 2Department of Biomedical Engineering, Columbia University, New York, NY.

RAPID FIRE PRESENTATIONS:

11:00 AM – 11:05 AM                     3

Immunocompetent, Vascularized, Autologous 3D Skin Model Reconstructed By Tissue Engineering

  1. Attiogbe1, S. Larochelle1, C. Mainzer2, A. Mauroux3, S. Bordes4, B. Closs4, C. Gilbert5, V. Moulin1;
    1LOEX institute, Université Laval, Québec, QC, CANADA, 2R&D, Silab, Saint Viance, FRANCE, 3Silab, Saint–Viance, FRANCE, 4R&D, Silab, Saint–Viance, FRANCE, 5CHU de Québec, Québec, QC, CANADA.

 

11:05 AM – 11:10 AM                     Additional Q&A

 

11:10 AM – 11:15 AM                     5

Acute Contact With Macrophages Induces Fibroblast Contraction – A Booster For Tissue Repair

  1. Ezzo1,2, J. B. Wang1, G. Pecoraro1, J. Firmino1, P. Pakshir1, B. Hinz1,2;
    1Faculty of Dentistry, University of Toronto, Toronto, ON, CANADA, 2Keenan Research Centre for Biomedical Science of the St. Michael’s Hospital, Laboratory of Tissue Repair and Regeneration, Toronto, ON, CANADA.

 

11:15 AM – 11:20 AM                     6

Matrix Bound Nanovesicles As A Novel Extracellular Matrix Therapy For The Treatment Of Rheumatoid Arthritis

  1. J. Crum1, K. Hall1, C. P. Molina1, G. S. Hussey1, E. Graham2, H. Li3, S. F. Badylak1;
    1University of Pittsburgh, Pittsburgh, PA, 2Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, 3Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA.

 

11:20 AM – 11:25 AM                     7

Wearable Engineered Human Skin With Region–specific Cellular, Extracellular And Mechanical Properties

  1. Pappalardo1, D. Alvarez–Cespedes1, S. Fang2, A. R. Herschman2, E. Jeon1, K. M. Myers2, J. W. Kysar2, H. E. Abaci1;
    1Dermatology, Columbia University, New York, NY, 2Mechanical Engineering, Columbia University, New York, NY.

 

11:25 AM – 11:30 AM                    8

Using Physiological Factors To Improve Self–assembled Skin Substitute Pigmentation

  1. Ferland1,2, B. Magne1,2, D. Larouche1,2, L. Germain1,2;
    1Centre de recherche en organogénèse expérimentale de l’Université Laval/LOEX and Department of Surgery, Faculty of Medicine, Université Laval, Québec, Canada, Quebec, QC, CANADA, 2CHU de Québec–Université Laval Research Center, Québec, Canada, Quebec, QC, CANADA.

 

 

 

Grand Ballroom East                     Session 2: Understanding the Path to Market for Musculoskeletal Tissue Engineered Products

Session Chairs: Lisa Larkin and George Christ

Keynote Speakers:
10:00 AM – 10:20 AM                     Do’s and Don’ts for TERM Startups: From Founding Through to                                                                             Commercialization
Michael Francis

10:20 AM – 10:40 AM                     Challenges and lessons learned from the commercialization of TERM Technologies
Robert Spiro

10:40 AM – 11:00 AM                     Understanding the Regulatory Considerations for the Path to Market for Autologous Therapies
Jennifer Woodell–May

11:00 AM – 11:30 AM                     Panel Discussion

 

Grand Ballroom West                   Session 3: Biomaterials for Endogenous Cardiovascular Repair

Session Chairs: Brandon Tefft and Ngan Huang
SYIS Co–Chair: Ishita Tandon

Keynote Speaker:                            Bioengineering Heart Tissue Function Using Microfabricated Elastomers
10:00 AM – 10:45 AM                    
Milica Radisic

ORAL PRESENTATIONS:

10:45 AM – 11:00 AM                    10

Covalent Peptide Modification Of Poly(Vinyl Alcohol) Promotes Endothelialization While Reducing Thrombosis

  1. E. Anderson1, N. M. Bates1, M. E. Fallon1, H. E. Heidenreich1, Y. Yao2, E. K. Yim2, M. T. Hinds1;
    1Biomedical Engineering, Oregon Health and Science University, Portland, OR, 2University of Waterloo, Waterloo, ON, CANADA.

 

11:00 AM – 11:15 AM                    11

Basement Membrane Of Tissue–engineered Small Diameter Vascular Extracellular Matrix Scaffolds Induce Human Endothelial Cell Quiescence

  1. A. Shortreed1,2,3, M. Lopera–Higuita1,3,4, S. Dasari5, L. G. Griffiths3;
    1Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, 2Department of Immunology, Mayo Clinic, Rochester, MN, 3Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, 4Department of Biomedical Engineering & Physiology, Mayo Clinic, Rochester, MN, 5Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.

 

11:15 AM – 11:30 AM                    133

Left And Right Ventricle Myocardial Matrix Hydrogels Enhance Therapeutic Potential Of Cardiac Progenitor Cells

  1. Hunter1, A. Hancko1, P. Shakya2, M. Davis2, K. Christman1; 1University of California San Diego, La Jolla, CA, 2Georgia Institute of Technology and Emory University, Atlanta, GA.

 

Osgoode Ballroom                         Session 4: Tissue Engineering Solutions for Craniofacial Regeneration

Session Chairs: Roberto Fanganiello and Akishige Hokugo
SYIS Co–Chair: Nicholas Fischer

Keynote Speaker:           

10:30 AM – 10:45 AM                    Tissue Engineering and Craniofacial Regeneration: What are the Innovations?
Pamela Yelick

ORAL PRESENTATIONS:

10:30 AM – 10:45 AM                    13
Multicentric Randomized Clinical Trial Using Bone Tissue Engineering Kit In Patients With Cleft Lip And Palate
D. F. Bueno
1, A. H. Tovo2, B. Dias3, C. C. Pinheiro4, D. S. Alencar3, D. L. Rocha4, D. Franco5, D. M. Vale6, G. L. Achoa7, H. M. Santos8, H. Cintra3, J. C. Coelli7, J. F. Cunha Filho8, M. Gamborgi7, M. V. Collares2, M. A. Almeida9, R. Faco10, R. C. Lauris10, R. M. Carvalho10, R. M. Pereira11, T. O. Ozawa10, R. L. Pacheco4, R. Riera4;

10:45 AM – 11:00 AM                    14
Osteogenic Application Of Diabetic Dental Pulp Cells By Hyperglycemia–upregulation
M. Kim1, H. Eom1, W. V. Giannobile2, C. Park1;
1Dental Biomaterials, Kyungpook National University, Daegu, KOREA, REPUBLIC OF, 2Harvard School of Dental Medicine, Boston, MA.

 

11:00 AM – 11:15 AM                    15

3d Bioprinted Biomimetic Bone Scaffolds For Mandibular Reconstruction

  1. Lee, H. Lee, C. Kengla, I. Kim, J. Yoo, A. Atala;
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston–Salem, NC.

11:15 AM – 11:30 AM                     17

Biphasic 3d–printed Osteochondral Biomaterial For Temporomandibular Condyle Regeneration

  1. Nedrelow, A. Rassi, B. Ajeeb, P. Huebner, M. Detamore;
    Biomedical Engineering, University of Oklahoma, Norman, OK.

 

11:30 AM – 1:00 PM                   Lunch (on own)

11:30 AM – 1:00 PM                   Women in TERM Networking Luncheon
Civic Ballroom South                   
Sponsored by: Burroughs Wellcome Fund; The University of Florida Department of BME; School of Biomedical Engineering at the University of British Columbia; University of Maryland Department of Bioengineering
Pre–Registration Required. Ticketed Session.

A highly regarded and popular event at the conference, the women’s luncheon serves to create a supportive network of women in TERM. Each annual luncheon focuses on a theme that is relevant to the community, providing a platform for attendees to engage with speakers and their peers while discussing the topic.

This year’s theme is “Navigating the New Normal”. The pandemic created massive disruptions to daily life, the workplace, as well as work–home boundaries, and continues to evolve 2 years later. Some changes, such as remote or hybrid workspaces, may remain long–term and will be important to navigate as trainees and early–career scientists advance in their careers. The pandemic has also shone a spotlight on the impact of societal inequities among women and minoritized groups. Studies indicate women have been disproportionately affected in their professions by the pandemic, largely due to shouldering the increased caregiving responsibilities for children and/or elderly family members. The objective of this workshop is to disseminate information about how academic institutions and industries are addressing these pandemic–related challenges, share insights into how institutions and industries will operate going forward given the issues brought to light by the pandemic, and to discuss strategies for navigating these challenges in the careers of women. Topics will include strategies for addressing gaps in training or research activity, professional networking in the era of hybrid or remote workplaces and managing boundaries between work and home life. Though open to all TERMIS attendees, this event will examine the issues that women in particular face and provide tools and support to women in TERM for navigating the “new normal”. The event is also aimed at informing those in mentoring and leadership positions within the TERMIS community of these issues, so they may be become better advocates for their female colleagues and trainees. To accomplish this, we will assemble a panel of women with a breadth of experiences in academic research, academic administration, entrepreneurship, and industry to provide their perspectives.

Speakers:
Molly Shoichet, University of Toronto
Gordana Vunjak–Novakovic, Columbia University
Elizabeth Csaszar, Notch Therapeutics
Mary Clare McCorry, Advanced Regenerative Medicine Institute

 

1:00 PM – 2:30 PM                     Scientific Concurrent Sessions 2

Grand Ballroom Centre                Session 5: 3D Bioprinting Methods and Applications

Session Chairs: Sang Jin Lee and John D. Jackson
SYIS Co–Chair: Marta Orlowska

Keynote Speakers:
1:00 PM – 1:30 PM                           Suspension Bath Bioprinting – Fundamentals and Applications

Megan Cooke

 

1:30 PM – 2:00 PM                           3D Bioprinting: Application-Driven Development
James J. Yoo


ORAL PRESENTATIONS:

2:00 PM – 2:15 PM                           18

Innovative Artificial Intelligence Hyper–personalized Organ Regeneration

  1. Kim;
    R&D Center, ROKIT AMERICA, Los Angeles, CA.

 

2:15 PM – 2:30 PM                          19

In Vivo Printing Of Engineered Multiscale Porous Scaffolds Restores Muscle Function After Volumetric Muscle Loss

  1. Samandari1, Y. Endo2, M. Karvar2, A. Mostafavi3, J. Quint1, I. Sinha2, A. Tamayol1;
    1Biomedical Engineering, UConn Health Center, FARMINGTON, CT, 2Harvard Medical School, Boston, MA, 3University of Nebraska–Lincoln, Lincoln, NE.

 

 

Grand Ballroom East                     Session 6: Nature as a Source of TERM Biomaterials and Strategies

Session Chairs: Rui Reis
SYIS Co–Chair: Bella Xu

ORAL PRESENTATIONS:

 

1:00 PM – 1:15 PM                          20

Over Coming Tissue Decellularization Deficits: A Balanced Approach Provides Best Results In The Lab And Clinic

  1. F. Gratzer1,2,3, M. Glazebrook4, S. Lu5, A. McLaren6, I. Costa7;
    1School of Biomedical Engineering, Dalhousie University, Halifax, NS, CANADA, 2Department of Surgery, Dalhousie University, Halifax, NS, CANADA, 3Department of Process Engineering and Applied Science, Dalhousie University, Halifax, NS, CANADA, 4Orthopaedic Surgery, Queen Elizabeth II Health Sciences Centre, Halifax, NS, CANADA, 5Surgery, St. Michael’s Hospital, Toronto, ON, CANADA, 6Orthopedic Surgery, St. Michael’s Hospital, Toronto, ON, CANADA, 7School of Nursing, Lakehead University, Thunder Bay, ON, CANADA.

 

1:15 PM – 1:30 PM                          21

Biomimetic Umbilical Cord Collagen Hydrogel Patch For Corneal Stroma Reconstruction

  1. Gunasekaran1,2, U. Tiruchirapalli Sivagnanam1;
    1Biological Materials Laboratory, CSIR Central Leather Research Institute, Chennai, INDIA, 2Department of Leather Technology, Anna University, Chennai, INDIA.

 

1:30 PM – 1:45 PM                          22

Monitoring Decellularization Via Absorbance Spectroscopy To Derive Extracellular Matrix Scaffolds: In Vitro And In Vivo Testing For Vocal Fold Application

  1. Mora1, A. Biehl2, E. W. Ozpinar2, M. E. Garcia2, D. Sze2, P. Sarker3, J. R. Enders4, S. Khan3, R. C. Branski5, D. O. Freytes2;
    1Chemical Engineering, University of Puerto Rico, Mayaguez, PR, 2Joint Department of Biomedical Engineering, NCSU/ UNC–Chapel Hill, North Carolina State University, Raleigh, NC, 3Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, 4Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC, 5Rehabilitation Medicine and Otolaryngology–Head and Neck Surgury, NYU– Grossman School of Medicine, New York, NY.

 

1:45 PM – 1:50 PM                           134

Incorporation Of Decellularized Cartilage Extracellular Matrix Nanoparticles Within Photo Reactive Colloidal Bioinks
M. R. Perez, K. J. Hogan, A. G. Mikos;
Bioengineering, Rice University, Houston, TX.

 

1:50 PM – 1:55 PM                           135

Comparison Of Ectopic Bone Formation Dynamics Using RhBMP6 In Autologous Blood Coagulum As A Carrier With Commercially Available RhBMP2 On An Absorbable Collagen Sponge
N. Ivanjko, N. Stokovic, M. Milesevic, S. Vukicevic;
Laboratory for Mineralized Tissues, School of Medicine University of Zagreb, Zagreb, CROATIA

 

1:55 PM – 2:00 PM                           136

A Dopamine-functionalized Hydrogel System For Therapeutic Delivery Of Extracellular Vesicles
J. Copus;

Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC.

 

2:00 PM – 2:15 PM                          24

Bioengineered Blood Clots As A Novel Material For Tissue Regeneration

  1. Jiang, G. Bao, J. Li;
    Mechanical Engineering, McGill University, Montreal, QC, CANADA.

2:15 PM – 2:30 PM                          25

Recombinant Human Bone Morphogenetic Protein 6 In Autologous Blood Coagulum With Synthetic Ceramic Particles Promotes Spinal Fusion In Sheep

  1. Stokovic1, N. Ivanjko1, M. Pecin2, A. Smajlovic2, N. Ivkic2, H. Capak3, Z. Vrbanac3, D. Vnuk2, D. Maticic2, S. Vukicevic1;
    1Laboratory for Mineralized Tissues, School of Medicine University of Zagreb, Zagreb, CROATIA, 2Clinics for Surgery, Orthopedics and Ophthalmology, Faculty of Veterinary Medicine University of Zagreb, Zagreb, CROATIA, 3Department of Radiology, Ultrasound Diagnostics and Physical Therapy, Faculty of Veterinary Medicine University of Zagreb, Zagreb, CROATIA.

 

 

Grand Ballroom West                   Session 7: Biomaterials and Immunomodulation
Sponsored by: KeAi Publishing

Session Chairs: Donghui Zhu and Kelvin Yeung
SYIS Co–Chair: Lorena Duarte

Keynote Speakers:
1:00 PM – 1:30 PM                           Design of Biomaterials to Scavenge Proinflammatory Factors

Kam Leong

 

1:30 PM – 2:00 PM                           Enabling the Practice of Regenerative Medicine
Guillermo Antonio Ameer

 

RAPID FIRE PRESENTATIONS:

2:00 PM – 2:05 PM                          26

Matrix–bound Nanovesicles As Selective Modulators Of The Immune Response

  1. Capella–Monsonis, R. J. Crum, S. Badylak;
    Surgery, University of Pittsburgh, Pittsburgh, PA.

2:05 PM – 2:10 PM                          27

Learning From Cell–Material Interactions To Improve MSC Immunomodulatory Potential

  1. Lagneau1, P. Tournier1, B. Halgand2, F. Loll1, C. Le Visage1, J. Guicheux2, V. Delplace1;
    1Regenerative Medicine and Skeleton, RMeS UMR 1229, Université de Nantes, Oniris, INSERM, Nantes, FRANCE, 2Regenerative Medicine and Skeleton, RMeS UMR 1229, Université de Nantes, Oniris, INSERM, CHU, Nantes, FRANCE.

 

2:10 PM – 2:15 PM                          28

Real–time Evaluation Of Local Delivery Vehicles For Cancer Immunotherapeutics Within Embedded Spheroid Cultures

  1. G. Wylie, V. Huynh;
    Chemistry and Chemical Biology, McMaster University, Hamilton, ON, CANADA.

 

2:15 PM – 2:20 PM                          29

Optimization Of Cell–based Therapies With Porous 3d Printed Scaffolds

  1. R. Lansberry, R. P. Accolla, J. Liang, A. Simmons, C. Stabler;
    Biomedical Engineering, University of Florida, GAINESVILLE, FL.

 

2:20 PM – 2:25 PM                          30

Therapeutic Potential Of Matrix Bound Nanovesicles In Rodent Model Of Ulcerative Colitis

  1. T. Hall, S. Fisher, G. S. Hussey, S. F. Badylak;
    University of Pittsburgh, Pittsburgh, PA.

 

2:25 PM – 2:30 PM                          31

Matrix–bound Nanovesicles Provide Mechanistic Insight Into Mechanisms Of Heart Disease Progression To Failure

  1. C. Cramer1,2, L. Mathews3,4, G. Hussey3,2, W. Schwarzmann5, V. Soman5, J. Sembrat6, M. Rojas6, C. McTiernan6, U. Chandran5, H. Turnquist7,3,4, S. F. Badylak3,2,1;
    1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 3Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 4Starzl Transplantation Institute, Pittsburgh, PA, 5Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, 6Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 7Department of Immunology, University of Pittsburgh, Pittsburgh, PA.

Osgoode Ballroom                         Session 8: A First Nations and Metis Perspective on Tissue Engineering & Regenerative Medicine

Session Chairs: Adam McInnes

Keynote Speakers:
1:00 PM – 1:10 PM                           Intro to Tissue Engineering and Regenerative Medicine

Adam McInnes

 

1:10 PM – 1:50 PM                           Presentation from Indigenous Elders and People with Lived Experiences
Mike Moser & Caroline Tait

 

1:50 PM – 2:30 PM                           Roundtable Discussion and Q&A with Audience

2:30 PM – 2:45 PM                    Transitional Break

2:45 PM – 4:15 PM                    Scientific Concurrent Sessions 3

Grand Ballroom Centre                Session 9: Bioreactors and Organs–on–chips in TERM

Session Chairs: Pedro Costa
SYIS Co–Chair: Zoubaire Moustaine

Keynote Speaker:

2:45 PM – 3:15 PM                           Organs-On-Chips & Biofabrication: A Path to Commercialization
Pedro Costa


ORAL PRESENTATIONS:

3:15 PM – 3:30 PM                          32

Engineering The External And Internal Cell Environment In Liver Tumor Spheroids Using A Microfluidic Device And Oxygenating Macf Microparticles

  1. Mansouri, N. Leipzig;
    Department of Chemical, Biomolecular, and Corrosion Engineering, University of Akron, Akron, OH.

3:30 PM – 3:45 PM                          33

Using A Bioengineered Immune–enhanced Tumor–on–a–chip (itoc) Platform To Improve T Cell Tumor–killing Capabilities

  1. Rodriguez, M. Kheradmandi, H. Sivakumar, F. Ilyas, J. Beane, A. Skardal;
    Department of Biomedical Engineering, The Ohio State University, Columbus, OH.

 

3:45 PM – 4:00 PM                          34

Intermittent Perfusion Improves Stem Cell Colony Size And Distribution In A 3d–bioprinted Chambered Model

  1. R. Komosa, W. Lin, B. M. Ogle;
    Biomedical Engineering, University of Minnesota, Minneapolis, MN.

 

RAPID FIRE PRESENTATIONS:

 

4:00 PM – 4:05 PM                          35

A Microphysiological System To Model The Endothelial–epithelial Interface

  1. G. McDuffie1, R. A. Burgess2, M. G. Helm1, E. Thomas2, A. Agarwal1;
    1Biomedical Engineering, University of Miami, Miami, FL, 2Pathology, University of Miami, Miami, FL.

 

4:05 PM – 4:10 PM                          36

Heart–on–a–chip Model Of Sars–cov–2 Cardiac Involvement And Treatment With Induced Pluripotent Stem Cell Derived Extracellular Vesicles

  1. Wu, M. Radisic, n. Rafatian, K. T. Wagner;
    University of Toronto, Toronto, ON, CANADA.

 

4:10 PM – 4:15 PM                          37

Design Of A Biomimetic 3D Stretchable Substrate For Growth And Maintenance Of Alveolar Epithelial Cells

  1. Nejatian1, F. Aoki2, A. McGuigan3, T. K. Waddell4, G. Karoubi2;
    1Institute of Biomaterials and Biomedical Engineering, University Health Network/University of Toronto, Toronto, ON, CANADA, 2Thoracic Surgery/Laboratory Medicine and Pathobiology, University Health Network/University of Toronto, Toronto, ON, CANADA, 3Department of Chemical Engineering, University of Toronto, Toronto, ON, CANADA, 4Thoracic Surgery, University Health Network/University of Toronto, Toronto, ON, CANADA.

 

 

Grand Ballroom East                     Session 10: Biomaterials to Direct Stem Cell Fate

Session Chairs: Jenny Robinson and Madhu Dhar
SYIS Co–Chair: Naveed Tavakol

Keynote Speaker:                            User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate
2:45 PM – 3:15 PM                           Cole DeForest

ORAL PRESENTATIONS:

3:15 PM – 3:30 PM                          38

Spatially Controlled Skin Morphogenesis Via Extracellular Matrix Cues And Morphogen Gradients

  1. Y. Jeon, A. Pappalardo, L. Sorrells, H. E. Abaci;
    Columbia University Irving Medical Center, New York, NY.

 

3:30 PM – 3:45 PM                          39

Biomimetic Hydrogels With Multi–component Cell Adhesive Ligands For Endothelial Cell Function

  1. Shayan1, R. Suhar2, S. Heilshorn2, N. Huang1;
    1Cardiothoracic Surgery, Stanford University, Palo Alto, CA, 2Materials Science & Engineering, Stanford University, Palo Alto, CA.

 

RAPID FIRE PRESENTATIONS:

 

3:45 PM – 3:50 PM                          40

In Vivo Validation Of A Continuous Gradient Porous Scaffold For Osteochondral Defect Repair In A Rabbit Model

  1. W. Smith1, S. Ali Akbari Ghavimi1, S. Logterman2, P. M. Gehret1, E. Capuana3, G. Conoscenti4, V. Brucato5, V. La Carrubba5, J. T. Lawrence2, R. Gottardi1;
    1Pulmonary Research, Children’s Hospital of Philadelphia, Philadelphia, PA, 2Orthopedic Surgery, Children’s Hospital of Philadelphia, Philadelphia, PA, 3Industrial and Digital Innovation, University of Palermo, Palermo, ITALY, 4Department of civil, environmental, aerospace, and materials engineering, University of Palermo, Palermo, ITALY, 5Engineering, University of Palermo, Palermo, ITALY.

 

3:50 PM – 3:55 PM                          Additional Q&A

 

3:55 PM – 4:00 PM                          137

Hypoosmolality Enhances Mesenchymal Stromal Cell Proliferation And Osteogenic Differentiation In 3d Viscoelastic Hydrogels

  1. R. Kollert1,2, T. H. Qazi3, V. Vogel2, D. J. Mooney4, G. N. Duda1;

1 Julius Wolff Institute & BIH Center for Regenerative Therapies, Charité – Universitätsmedizin Berlin, Berlin, GERMANY, 2Department of Health Sciences and Technology, ETH Zurich, Zurich, SWITZERLAND, 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 4 John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA.

 

4:00 PM – 4:05 PM                          42

Engineering A Matrix To Improve Reproducibility Of Intestinal Organoids

  1. C. Martin–Villa1, K. C. Klett2, S. C. Heilshorn3;
    1Department of Bioengineering, Stanford University, Stanford, CA, 2Department of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, 3Department of Materials Science & Engineering, Stanford University, Stanford, CA.

 

4:05 PM – 4:10 PM                           43

Biomimetic Hierarchical Patterning And Honey Incorporation In Porous Silk Fibroin Scaffold Improve Mesenchymal Stem Cell Proliferation, Differentiation, Epithelial Transition, And Restrain Senescence

  1. Mukhopadhyay1, A. Gope1, J. Chatterjee1, R. Mukherjee2;
    1School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, INDIA, 2Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur, INDIA.

 

4:10 PM – 4:15 PM                          44

Additive Manufacturing Strategies To Fabricate Novel Biomimetic Carbon–based Nanocomposites To Control Stromal Cell Differentiation

  1. Dhar1, S. Newby2, A. MacDonald2, S. Bourdo3, M. Hung4;
    1University of Tennessee, Knoxville, TN, 2Large Animal Clinical Sciences, University of Tennessee, Knoxville, TN, 3Center for Integrative Nanotechnology Sciences, University of Arkansas, Little Rock, AR, 4Roseman University of Health Sciences, South Jordan, UT.

 

 

Grand Ballroom West                   Session 11: Respiratory, Urologic, & Gastrointestinal Tissue Engineering

Session Chairs: Andreas Kaasi and Riccardo Gottardi
SYIS Co–Chair: Zheng hong Tan

ORAL PRESENTATIONS:

2:45 PM – 3:00 PM                          45

A Decellularized Cartilage Biomaterials Approach To Pediatric Laryngotracheal Reconstruction

  1. Gehret1, S. Ali Akbari Ghavimi2, I. Jacobs2, R. Borek2, A. Dumas1, R. Gottardi3,2;
    1Bioengineering, University of Pennsylvania, Philadelphia, PA, 2Children’s Hospital of Philadelphia, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA.

 

3:00 PM – 3:15 PM                          46

De– And Recellularized Urethral Reconstruction With Autologous Buccal Mucosal Cells Implanted In An Ovine Animal Model

  1. Håkansson1, K. Larsson2, L. Jenndahl1, R. Strehl3, S. Simonsson4, M. Johansson5, T. O. Ekerhult2;
    1RISE, Gothenburg, SWEDEN, 2Urology, Sahlgrenska University Hospital, Institution of clinical sciences, Gothenburg, SWEDEN, 3Verigraft AB, Gothenburg, SWEDEN, 4Laboratory medicine, Sahlgrenska University Hospital, Institution of biomedicine, Gothenburg, SWEDEN, 5Clinical Pathology, Sahlgrenska University Hospital, Institution of clinical sciences, Gothenburg, SWEDEN.

 

3:15 PM – 3:30 PM                          47

Development And Delivery Of Renal Progenitor Organoids For Effective Integration In Vivo

  1. Lim, I. Kim, J. Kim, A. Atala, J. Jackson, J. Yoo;
    Wake Forest Institution for Regenerative Medicine, Winston Salem, NC.

 

3:30 PM – 3:45 PM                          48

Lung–mimetic Sealant For Repairing Pulmonary Air Leak

  1. Kim, S. Mir, J. Chen;
    Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ.

 

RAPID FIRE PRESENTATIONS:

 

3:45 PM – 3:50 PM                          49

Gene Expression Of Tracheal Stenosis Suggests That Hypertrophic Tissues Lack Anti–inflammatory Macrophages, TLR4–expressing Cells, And Differentiating Airway Epithelial Cells

  1. Weber1, Z. Muslim1, M. Baig1, K. Poulikidis1, A. Al Shetawi2, F. Bhora1;
    1Nuvance Health, Danbury, CT, 2Nuvance Health, Poughkeepsie, NY.

 

3:50 PM – 3:55 PM                          50

In Silico Modeling Of BEAS–2B Cell Population Dynamics

  1. Mostofinejad1, A. E. Marin–Araujo2,3, D. A. Romero1, T. K. Waddell4,2,5, G. Karoubi4,1,6, C. H. Amon1,2;
    1Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Latner Research Laboratories, University Health Network, Toronto, ON, CANADA, 4Latner Thoracic Surgery Laboratories, University Health Network, Toronto, ON, CANADA, 5Institute of Medical Sciences, University of Toronto, Toronto, ON, CANADA, 6Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CANADA.

 

3:55 PM – 4:00 PM                          51

Tissue Engineering Solutions For Vaginal Reconstruction

  1. Brownell, S. Chabaud, S. Bolduc;
    Faculté de medicine, Université Laval, Québec, QC, CANADA.

 

4:00 PM – 4:05 PM                           138

Human Organ-specific Engineered Urethra Substitute: In Vitro Optimization And Characterization

  1. Caneparo, S. Chabaud, S. Bolduc;

Université Laval, Québec, QC, CANADA.

 

4:05 PM – 4:10 PM                          52

Nanoparticles Remain In The Pelvic Region And Promote Elastin Repair In A Pelvic Organ Prolapse Mouse Model

  1. Dahal1, B. Balog2, K. Deng2, M. Kuang2, K. Woolley2, S. Thampi1, A. Ramamurthi1, M. Damaser2;
    1Bioengineering, Lehigh University, Bethlehem, PA, 2Biomedical Engineering, Lerner Research Institute, Cleveland, OH.

 

4:10 PM – 4:15 PM                           139

Selective Replacement Of The Airway Epithelium In In Vitro-cultured Rat Trachea

  1. Kim, J. Chen, S. Mir;

Biomedical Engineering department, Stevens Institute of Technology, Hoboken, NJ.

 

 

Osgoode Ballroom                         Session 12: Frontiers in Spatiotemporal Control for Neural Tissue Engineering 

Session Chairs: Adele Doyle and Stephanie Seidlits
SYIS Co–Chair: Amanda Juraski

Keynote Speaker:                            Bioprinting Personalized Neural Tissue Models
2:45 PM – 3:15 PM                           Stephanie Willerth

ORAL PRESENTATIONS:

3:15 PM – 3:30 PM                          53

Motor Function Evaluation Of a Prevascularized Cell–based Tissue–engineered Nerve Tube for Regeneration Of A Rat Sciatic Nerve Defect

  1. Thibodeau1,2, T. Galbraith1, C. Fauvel1, H. Khuong1,2, F. Berthod1,2;
    1LOEX, centre de recherche du CHU de Québec–Université Laval, Québec, QC, CANADA, 2Département de Chirurgie, Faculté de médecine, Université Laval, Québec, QC, CANADA.

 

3:30 PM – 3:45 PM                          54

Enhancing Axon Regeneration And Orienting Axon Extension Using Scaffold–free Dental Pulp Stem Cell–based Nerve Conduits 

  1. D. Drewry1, M. T. Dailey2, K. Rothermund3, F. N. Syed–Picard3;
    1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2Department of Oral and Maxillofacial Surgery, University of Pittsburgh, Pittsburgh, PA, 3Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA.

 

3:45 PM – 4:00 PM                          55

Engineered Thermostabilized Chondroitinase ABC To Enable Tissue Regeneration Post Stroke

  1. Letko Khait1, S. Zuccaro1, M. Hettiaratchi1,2, M. O’meara3, Q. Sirianni1, M. Shoichet1,4;
    1Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 2Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, 3Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 4Biomedical Engineering, University of Toronto, Toronto, ON, CANADA.

 

4:00 PM – 4:15 PM                          56

Effects Of Enriched Astrocyte Phenotypic On ECM Composition And Interneuron Axon Growth Promotion

  1. Vardhan, A. Merchant, S. Sakiyama–Elbert;
    Biomedical Engineering, UT Austin, Austin, TX.

 

4:15 PM – 4:45 PM                           Coffee Break in Exhibit Hall
Sheraton Hall A – F

4:15 PM – 4:45 PM                        TWIG Organizational Meetings
Grand Ballroom Centre                Skin, Wound Healing, and Inflammation
Grand Ballroom East                     Dental & Craniofacial
Grand Ballroom West                   Respiratory, Urologic and Gastrointestinal

Osgoode Ballroom                   Stem Cells & Cell Therapies & Developmental Biology and Cell Signaling

 

 

4:45 PM – 6:15 PM                           Scientific Concurrent Sessions 4

 

Grand Ballroom Centre                Session 13: Recent Progress in Cell Therapy for Regenerative Medicine & Cancer Treatment

Session Chairs: Nasim Annabi
SYIS Co–Chair: Yasmin Alshoubaki

Keynote Speaker:                            Metacells: Redesigning Living Cells for Regenerative Medicine 2:45 4:45 PM – 5:30 PM                          Farshid Guilak

ORAL PRESENTATION:

5:30 PM – 5:45 PM                          58

Incidence And Function Of Matrix–bound Nanovesicles Through Evolution

  1. D’Angelo1, S. Johnson1, L. Quijano1, S. El–Mossier1, B. Palo2, J. Birkhimer1, S. F. Badylak1;
    1University of Pittsburgh, Pittsburgh, PA, 2University of Michigan, Ann Arbor, MI.

 

RAPID FIRE PRESENTATIONS:

 

5:45 PM – 5:50 PM                          59

Personalized Tumoroids Of Ovarian Cancers For Studying Cancer Stem–like Cell Regulation And Chemoresistance

  1. Bregenzer1, P. Mehta2, K. Burkhard1, D. Zamarin3, Y. Yang–Hartwich4, G. Mehta1,2,5;
    1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Materials Science and Engineering, University of Michigan, Ann Arbor, MI, 3Gynecologic Medical Oncology and Immunotherapeutics, Memorial Sloan Kettering Cancer Center, New York, NY, 4Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, Yale University, New Haven, CT, 5Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI.

 

5:50 PM – 5:55 PM                          Additional Q&A

5:55 PM – 6:00 PM                          61

Probing Notch1–dll4 Signaling In Osteogenic Differentiation Of Human Mesenchymal Stem Cells Using Single Cell Nanobiosensor

  1. Wang;
    Department of Chemistry, Chemical and Biomedical Engineering, University of New Haven, West Haven, CT.

 

6:00 PM – 6:05 PM                          62

Generation Of Tracheal Grafts In A Bioreactor With Human Induced Pluripotent Stem Cell–Derived Airway Progenitors

  1. Varma1, S. Rostami1, A. Marin–Araujo1, F. Aoki1, D. Romero2, C. Amon2, T. K. Waddell3, S. Haykal1, G. Karoubi1;
    1University Health Network/University of Toronto, Toronto, ON, CANADA, 2University of Toronto, Toronto, ON, CANADA, 3Thoracic Surgery, University Health Network/University of Toronto, Toronto, ON, CANADA.

 

6:05 PM – 6:10 PM                          63

Clonal Mesenchymal Stromal Cell Sheets Exhibit Enhanced Immunomodulatory Properties

  1. M. Dunn1,2, S. Kameishi2, D. W. Grainger1,2, T. Okano3,2;
    1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, 2Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 3Institute for Advanced Biomedical Sciences, Tokyo Women’s Medical University (TWIns), Tokyo, JAPAN.

 

6:10 PM – 6:15 PM                          64

Differences In Human And Animal Primary Neural Stem Cell Responses To Inflammatory And Regenerative Cues

  1. Galuta1, D. Ghinda1,2,3, R. Sandarage1, J. F. Kwan1, S. Chen4, A. Auriat4, E. C. Tsai1,2,3;
    1Neuroscience, University of Ottawa, OTTAWA, ON, CANADA, 2Ottawa Hospital Research Institute, Ottawa, ON, CANADA, 3The Ottawa Hospital, Ottawa, ON, CANADA, 4Ottawa Hospital Research Institute, OTTAWA, ON, CANADA.

 

 

Grand Ballroom East                     Session 14: Distinguished TERMIS Travel Awardees

Session Chairs: Penney Gilbert and Jose Cadavid
SYIS Co–Chair: Lena Neufeld

ORAL PRESENTATION:

4:45 PM 5:00 PM                           121

Synthesis Of Catheters With Antifouling Properties Using Gamma Radiation–induced Zwitterionic Grafts

  1. Duarte–Peña, E. Bucio–Carrillo;
    Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares UNAM, Mexico City, MEXICO.

 

5:00 PM 5:15 PM                          122

Characterization And Evaluation Of Infusible Extracellular Matrix Derived Biomaterial Binding To Damaged Endothelium

  1. Diaz1, A. Banka2, M. Vratsanos3, K. Gnanasekaran3, N. Gianneschi4, L. Eniola–Adefeso2, K. Christman1;
    1Bioengineering, UCSD, La Jolla, CA, 2Chemical Engineering, Univeristy of Michigan, Ann Arbor, MI, 3Chemistry, Northwestern University, Evanston, IL, 4Chemistry, Materials Science and Engineering, Biomedical Engineering, Northwestern University, Evanston, IL.

 

5:15 PM 5:30 PM                          123

Effects Of Carrier Solutions On The Viability And Efficacy Of Canine Adipose–derived Mesenchymal Stem Cells

  1. Sultana1, A. Dayem2, S. Lee2, S. Cho2, J. Lee3,4;
    1Biomedical Science, Florida State University, Tallahassee, FL, 2Department of Stem Cell and Regenerative Biotechnology, Konkuk university, Gwangjin–gu, KOREA, REPUBLIC OF, 3Biomedical Science and Technology, Konkuk university, Gwangjin–gu, KOREA, REPUBLIC OF, 4Department of Veterinary Obstetrics and Theriogenology, Konkuk university, Gwangjin–gu, KOREA, REPUBLIC OF.

 

5:30 PM 5:45 PM                          124

High–stiffness, Bioprintable Cartilage Matrix Hydrogels That Promote Cell Viability And Adhesion

  1. A. Kiyotake1, M. E. Cheng1, E. E. Thomas2, M. S. Detamore1;
    1Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 2Biomedical Engineering, University of Michigan, Ann Arbor, MI.

 

5:45 PM 6:00 PM                          125

Novel Human Placental Derived Extracellular Matrix For Healing Estrogen–deprived Elderly Chronic Skin Wounds

  1. D. Zomer1, P. McFetridge2, P. S. Cooke1;
    1Physiological Sciences, University of Florida, Gainesville, FL, 2Biomedical Engineering, University of Florida, Gainesville, FL.

 

6:00 PM – 6:15 PM                          126

Comparison Of Collagen II And Decellularized Hyaline Cartilage Scaffolds Derived From Bovine Trachea For Cartilage Tissue Engineering

  1. M. Flórez, R. A. Jiménez, M. A. Torres, M. R. Fontanilla;
    Pharmacy, Universidad Nacional de Colombia, Bogotá, COLOMBIA.

 

 

Grand Ballroom West                   Session 15: Cell Therapeutic Approaches for Retinal Degenerative Diseases

Session Chairs: Kapil Bharti and Molly Shoichet
SYIS Co–Chair: Mickael Dang

Keynote Speaker:                            Treating Inherited Retinal Degenerative Blindness
4:45 PM – 5:15 PM                           Budd A. Tucker

ORAL PRESENTATIONS:

5:15 PM – 5:30 PM                          65

Sustained Release Of RdCVF–Sh3 To Rescue Cone Photoreceptor Death

  1. Huo1, C. Teal2, D. Isaacs3, M. Ho2, H. Harada4, T. Léveillard5, P. Monnier6, M. Shoichet1,3,2;
    1Institute of Medical Sciences, University of Toronto, Toronto, ON, CANADA, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 3Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 4Vision Division, Krembil Research Institute, Toronto, ON, CANADA, 5Department of Genetics, Institut de la Vision, Paris, FRANCE, 6Department of Physiology, University of Toronto, Toronto, ON, CANADA.

 

5:30 PM – 5:45 PM                          66

Injectable And Biodegradable Vitreous Substitute

  1. E. Baker1, A. Forman1, H. Cui1, M. Dang1, R. Devenyi2, M. S. Shoichet1;
    1Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, ON, CANADA, 2Ophthalmology & Vision Science, University of Toronto, Toronto, ON, CANADA.

 

5:45 PM – 6:00 PM                          67

Matrix Bound Nanovesicles Reduce Neuroinflammation And Protect Retinal Ganglion Cells Following Intracameral Injection Of Hyaluronic Acid Modeling Glaucoma

  1. Chang, M. Dewey, S. Badylak;
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.

 

6:00 PM – 6:15 PM                          68

Optic Nerve Regeneration With Matrix–bound Nanovesicles And Fluvastatin

  1. J. Dewey1, T. Kuwajima2, J. Chang1, G. Campbell1, S. F. Badylak1;
    1University of Pittsburgh, Pittsburgh, PA, 2Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA.

 

 

Osgoode Ballroom                         Session 16: Biofabrication and Software Tools in TERM

Session Chairs: Pedro Costa and James Yoo
SYIS Co–Chair: Elizabeth Komosa

Keynote Speakers:
4:45 PM – 5:15 PM                           Computationally–driven Strategies for Tissue Engineering and

Regenerative Medicine

Adele Doyle

 

5:15 PM – 5:45 PM                           3D Bioprinting and Translational Considerations

James Yoo

 

ORAL PRESENTATIONS:

 

5:15 PM – 6:00 PM                          69

Microfluidic–enabled Biofabrication Of 3D Hydrogel Architectures And Light–driven Digitalization Of Dynamic Cancer Responses

  1. F. Guimarães1, L. Gasperini1, R. Ahmed2, A. P. Marques1, U. Demirci2, R. L. Reis1;
    13B’s Research Group, University of Minho, Guimarães, PORTUGAL, 2Canary Center for Cancer Early Detection, Stanford University School of Medicine, Radiology Department, Palo Alto, CA.

 

6:00 PM – 6:15 PM                          70

A Perfusable Vascularized Placental Barrier Model Utilizing Human Trophoblast Stem Cells

  1. Kouthouridis, L. Abdul, A. Sotra, S. Raha, B. Zhang;
    McMaster, Hamilton, ON, CANADA.

 

6:15 PM – 7:00 PM                    Announcement & Awards Presentations

Grand Ballroom Centre & West                TERMIS–AM Educational, Training & Outreach Award: Patricia Pranke, PhD
Outstanding Postdoc Award: Jakob Townsend, PhD
Young Investigator Award: Fatima Syed–Picard, PhD
Mary Ann Liebert, Inc. Outstanding Student Award: Courtney Johnson

7:00 PM – 9:00 PM                     Exhibit Viewing / Reception / Poster Session 2
Sheraton Hall A – F

8:30 PM – 9:30 PM                     2023 Planning Team Meeting
Simcoe/Dufferin, 2nd Floor

8:30 PM – 9:30 PM                     SYIS Social
Civic Ballroom North/Civic Ballroom Foyer

Pre–Registration Required. Ticketed event.

 

6:00 AM – 7:30 PM                           Registration

Vide Foyer

6:15 AM – 7:30 AM                     SYIS Morning Walk/Run
Civic Ballroom North / Civic Ballroom Foyer

7:00 AM – 8:00 AM                     Sponsor Satellite Sessions
Osgoode Ballroom

7:30 AM – 7:20 AM                    CELLINK – “Developing Patient Specific Tissue Models Using a High Throughput Light–based Bioprinter”

Using a novel DLP based bioprinting method, we developed a patient specific biomimetic model for spinal cord injury repair. The model effectively captured the spinal cord anatomy and mechanical property leading to effective neural stem cell delivery and maturation in vivo at the spinal cord lesion site. Given the microscale printing resolution of our bioprinter, linear microchannels were readily fabricated in the biomimetic implant to align and guide regenerating axons for functional recovery. The bioinks used for printing the model were highly biocompatible with tunable degradation rate which significantly reduced foreign body reaction to the implant and further improved functional outcomes. The bioprinting platform and methodology developed here can be readily extended to other stem cell delivery and therapeutic applications as well as disease modeling purposes.

7:30 AM – 7:50 AM                    ARMI|BioFab – “Translating Tissue Technologies from Lab Bench to Commercial Manufacturing Line”

The path to commercialization of a tissue product introduces unique challenges in process scalability, product consistency, and high final product costs. Furthermore translating these technologies requires navigating a complex set of regulatory guidelines, recruiting a qualified workforce, and raising funds to support development. The Advanced Regenerative Manufacturing Institute (ARMI) is non–profit organization whose mission is to make practical the scalable, consistent, cost–effective manufacturing of cells, tissue and organs. ARMI is carrying out its mission by convening a diverse ecosystem of academic, industry, and nonprofit organizations to drive impactful advanced research and development activities that address TEMP manufacturing capability gaps. ARMI and its members are working to:
– Develop platform technologies for the manufacturing of cells, tissues and organs that are responsive to industry needs
– Apply technology development to demonstrate scalable, modular, automated and closed manufacturing for cell, tissue and organ biofabrication
– Close the skills gap in tissue and organ manufacturing by providing lifelong training opportunities
– Disseminate knowledge and technologies through membership community engagement
– Focus early on developing a conducive regulatory strategy
– Develop and implement standards into manufacturing practice
Please join us for this scientific session to learn more about the translation work ARMI is funding and how you could engage with ARMI to advance your science toward commercialization.

8:00 AM – 9:00 AM                     Plenary Symposium 3: Andres Garcia, PhD
Grand Ballroom Centre & West Synthetic Hydrogels for Regenerative Medicine

9:00 AM – 9:30 AM                     TERMIS–AM Lifetime Achievement Award: Laura Niklason, PhD

Grand Ballroom Centre & West

9:30 AM – 10:00 AM                   Coffee Break in Exhibit Hall
Sheraton Hall A – F

9:30 AM – 10:00 AM                      TWIG Organizational Meetings

Grand Ballroom Centre                Commercialization & Regulation
Grand Ballroom East                     Neural & Spine
Grand Ballroom West                   Ophthalmologic
Osgoode Ballroom                   Biofabrication & Bioreactors

10:00 AM – 11:30 AM                 Scientific Concurrent Sessions 5

Grand Ballroom Centre                Session 17: Skin, Wound Healing, and Inflammation Part 2

Session Chairs: Brice Magne
SYIS Co–Chair: Jonathan Dorogin

ORAL PRESENTATIONS:

 

10:00 AM – 10:15 AM                    127

Accelerated Production Of Clinical Grade Reconstructed Skin Substitutes From Decellularized Tissue–engineered Dermal Matrices For The Treatment Of Burn Patients

  1. Demers, B. Magne, M. Lemire–Rondeau, R. Guignard, F. Auger, L. Germain;
    Département de Chirurgie, LOEX, Université Laval, Québec, QC, CANADA.

 

10:15 AM – 10:30 AM                    128

Effect of Neuropeptides on Reepithelialization and Angiogenesis in Skin Wound Healing Models Produced from Diabetic Patient Cells

  1. M. Lemarchand, T. De Serres–Bérard, S. Bellenfant, T. Galbraith, F. Berthod;
    Surgery, CHU de Québec – Université Laval, Québec, QC, CANADA.

 

10:30 AM – 10:45 AM                    129

Antibacterial Poly(oligoethylene Glycol Methacrylate) (poegma)–based Nanofibrous Hydrogel Scaffolds For Wound Healing

  1. Xu, G. Randhawa, M. Lamb, E. Cudmore, T. Hoare;
    Chemical Engineering, McMaster University, Hamilton, ON, CANADA.

 

10:45 AM – 11:00 AM                    130

Tridimensional Cell Culture Of Dermal Fibroblasts Promotes Exosome–mediated Secretion Of Extracellular Matrix Proteins

  1. Clément1, V. Roy1, L. Touzel Deschênes2, N. Dupré3, F. Gros–Louis4;
    1Médecine, Université Laval, Quebec, QC, CANADA, 2Regenerative Médecine, CRCHUQ, Québec, QC, CANADA, 3Neurology, CHU de Québec, Quebec, QC, CANADA, 4Surgery, Université Laval, Quebec, QC, CANADA.

 

11:00 AM – 11:15 AM                    131

Novel 3D Hydrogel System For Tailoring Stem Cell Biologics To Improve Wound Healing

  1. Hodge1, A. Mellott2, J. Robinson3;
    1Bioengineering, University of Kansas, Lawrence, KS, 2Plastic Surgery, University of Kansas Medical Center, Kansas City, KS, 3Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS.

 

11:15 AM – 11:30 AM                    132

Polyphosphate Releasing Biocompatible Hydrogel Nanoparticle Emulsions For Chronic Wound Healing

  1. Negru1, F. Borges2, J. Park1, Y. Tsai1, S. Hyoju3, O. Zaborina3, M. Vaicik1, F. Teymour2, J. Alverdy3, G. Papavasiliou1;
    1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, 2Chemical Engineering, Illinois Institute of Technology, Chicago, IL, 3University of Chicago, Chicago, IL.

 

Grand Ballroom East                     Session 18: Articular Cartilage Bioengineering & Regeneration

Session Chairs: Tiago Fernandes and Lisa Larkin
SYIS Co–Chair: Emi Kiyotake

Keynote Speakers:
10:00 AM – 10:30 AM                     The Blueprint of Cartilage and Early OA Treatment Development

Mark Hurtig

ORAL PRESENTATIONS:

 

10:30 AM – 10:45 AM                    71

Utilizing Auto–regulated RUNX2 Suppression To Improve MSC–derived Cartilage Matrix Accumulation During Synovial Inflammation

  1. Kaur1, A. Knights2, T. Maerz2, R. Coleman1;
    1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Orthopedic Surgery, University of Michigan, Ann Arbor, MI.

 

10:45 AM – 11:00 AM                    72

Biomechanical Analysis Of A Cell Therapy And Tissue Engineering Strategy For Articular Cartilage Restoration – A Pre–clinical Study

  1. R. Faria1, J. P. Santanna1, I. D. Assad1, C. C. Pinheiro2, T. L. Fernandes1, D. F. Bueno2, A. J. Hernandez1;
    1Sports Medicine, Universidade de Sao Paulo, Sao Paulo, BRAZIL, 2Hospital Sírio–Libanes, Sao Paulo, BRAZIL.

 

11:00 AM – 11:15 AM                    73

Loading Of Tissue–engineered Cartilage Determines The Fate Of Chondrocyte

  1. Kim, I. Cohen, L. Bonassar;
    Cornell University, Ithaca, NY.

 

11:15 AM – 11:30 AM                    74

Acceleration Of Scaffold–free Hyaline Cartilage Formation By Layering Juvenile Chondrocyte Sheets

  1. F. Metzler1,2, M. Kondo2, D. W. Grainger1,2, T. Okano2,3;
    1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, 2Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, 3Institute for Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University (TWIns), Tokyo, JAPAN.

 

Grand Ballroom West                   Session 19: Business Plan Competition – Presentation of Full Business Plan Proposals

Session Chairs: Chelsea Bahney and Michael Francis

 

Presenting Finalists:

Pascal Medical Start–up
Jingyao Deng

Pumpinheart
Donald Hickey

Re:pair Therapeutics
Luca Hategan

 

Osgoode Ballroom                         Session 20: Regeneration in the Context of Aging

Session Chairs: Hang Lin and Rocky Tuan
SYIS Co–Chair: Erik Jacques

Keynote Speaker:
10:00 AM – 10:30 AM                     Aging of the Synovial Joint: Disease Pathogenesis, Tissue Chip Models, and Regenerative Therapies

Rocky Tuan

ORAL PRESENTATIONS:


10:30 AM – 10:45 AM
                   75

Facilitation Of Bone Defect Healing By IL–4 Over–expressing MSCs

  1. B. Goodman1, N. Zhang2, M. Ueno3, F. Yang4;
    1Orthopaedic Surgery and Bioengineering, Stanford University, Redwood City, CA, 2Orthopaedic Surgery, Stanford University, Stanford, CA, 3Orthopaedic Surgery, Saga University, Saga, JAPAN, 4Orthopaedic Surgery and Bioengineering, Stanford University, Stanford, CA.

 

10:45 AM – 11:00 AM                    76

Nap1l2 Drives Mesenchymal Stem Cell Senescence

  1. Hu, L. Xing, D. Liu;
    Department of Endodontics, Tianjin Medical University School of Stomatology, Tianjin, CHINA.

 

11:00 AM – 11:15 AM                    77

Loss Of Vitamin A Metabolism And Retinoic Acid Signaling In Aging Drives Muscle Stem Cell Dysfunction

  1. Fraczek, C. Aguilar;
    Biomedical Engineering, University of Michigan, Ann Arbor, MI.

 

11:15 AM – 11:30 AM                    78

Surface Functionalized Stem Cells Derived Extracellular Vesicles For Vascular Elastic Matrix Regenerative Repair

  1. Thampi, A. Ramamurthi;
    Bioengineering, Lehigh University, Bethlehem, PA.

 

 

11:30 AM – 1:00 PM                  Lunch on Own

11:30 AM – 1:00 PM                   SYIS Student Meet Mentor Lunch
Civic Ballroom South
                    Sponsored by: Medicine by Design (MbD)
Pre–Registration Required. Ticketed sessions.

1:00 PM – 2:30 PM                     Scientific Concurrent Sessions 6

Grand Ballroom Centre                Session 21: 3D Tissue–Engineered Cancer/Disease Modeling and Organoids Part 1

Session Chairs: Eliza Fong and Rui Reis
SYIS Co–Chair: Nila Wu

Keynote Speaker:
1:00 PM – 1:20 PM                           An Engineered 3D In Vitro Model Of Pancreatic Cancer To Assess The Effect Of Tissue Architecture And Fibroblast Content On Cellular Phenotype And Behavior

J.L. Cadavid

 

ORAL PRESENTATIONS:

1:20 PM – 1:35 PM                          79

Generation Of An Organoid Model Of Adrenocortical Carcinoma Drug Response, Invasion, And Metastasis

  1. Sivakumar1, M. Rodriguez1, X. Zheng2, J. Zent1, K. Nairon1, J. Leight1, P. Dedhia1, A. Skardal1;
    1Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 2Division of Surgical Oncology, The Ohio State University, Columbus, OH.

 

1:35 PM – 1:50 PM                          83

Effects of Matrix Stiffness On Glioblastoma Metabolism

  1. K. Seidlits1, A. Sohrabi1, A. Lefebvre2, M. Condro3, H. I. Kornblum3, M. A. Digman2;
    1Biomedical Engineering, University of Texas at Austin, Austin, TX, 2Biomedical Engineering, University of California, Irvine, Irvine, CA, 3University of California, Los Angeles, Los Angeles, CA.

 

1:50 PM – 2:05 PM                          81

Patient–derived Myeloma 3d Organoid Model To Study Effects On Tumor Microenvironment

  1. M. Rashad1, J. Scolnick2, G. Insuasti3, G. Porada4, C. Rodriguez1;

1Hematology/Oncology, Atrium Health Wake Forest Baptist, Winston Salem, NC, 2National University of Singapore, Singapore, SINGAPORE, 3Department of Pathology, Atrium Health Wake Forest Baptist, Winston Salem, NC, 4Wake Forest Institute for Regenerative Medicine, Winston Salem, NC.

 

 

2:05 PM – 2:20 PM                          82 – Microengineered Perfusable 3d–bioprinted Cancer Model For Mimicry Of Tumor Microenvironment

  1. Neufeld, R. Satchi–Fainaro;
    Physiology and Pharmacology, Tel Aviv University, Tel Aviv, ISRAEL.

 

2:20 PM – 2:30 PM                           140

Microgravity-induced Mitochondrial Dysfunction In Human IPSC-based 3d Engineered Heart Tissues

  1. B. Mair1, J. H. Tsui1, T. Higashi2, L. Stoddart1, M. A. Williams1, E. Ahn1, P. H. Lee3, S. Countryman4, N. J. Sniadecki2, D. Kim1;

1Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 2Mechanical Engineering, University of Washington, Seattle, WA, 3Pathology and Laboratory Medicine, Brown University, Providence, RI, 4Bioserve Space Technologies, Boulder, CO.

 

 

Grand Ballroom East                     Session 22: Strategies for Regeneration of Complex Muscle Defects

Session Chairs: George Christ and Michael McClure
SYIS Co–Chair: Jacqueline Larouche

Keynote Speaker:

1:00 PM – 1:30 PM                           Regenerative Therapeutics for Repair of Polytraumatic Volumetric Muscle Loss Injuries

George Christ


ORAL PRESENTATION:

1:30 PM – 1:45 PM                          84

Neutrophil And Natural Killer Cell Imbalances Prevent Muscle Stem Cell Mediated Regeneration Following Murine Volumetric Muscle Loss

  1. Larouche1, S. Kurpiers1, P. Fraczek1, B. Yang1, C. Davis2, J. Castor–Macias1, K. Sabin1, S. Brooks2, C. Aguilar3;
    1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, 3Biomedical Engineering, Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI.

 

Keynote Speaker:

1:45 PM – 2:00 PM                           Super Regenerators and Lack of Regeneration After Volumetric Muscle Loss Injury: What is the Connection?

Sarah Greising

 

ORAL PRESENTATIONS:

2:00 PM – 2:15 PM                          85

3d Printed Composite Skeletal Muscle Fascicles For The Treatment Of Volumetric Muscle Loss

  1. P. Quint, M. Samandari, A. Tamayol;
    Biomedical Engineering, University of Connecticut Health Center, Farmington, CT.

 

2:15 PM – 2:30 PM                          86

Combination Therapy For Enhanced Functional Recovery And Neuromuscular Regeneration Of Volumetric Muscle Loss Injuries

  1. Sergent1, J. Passipieri1, A. Killaars2, S. Brown2, R. Upasani1, K. Healy2, G. Christ1;
    1Biomedical Engineering, University of Virginia, Charlottesville, VA, 2University of California, Berkeley, Berkeley, CA.

 

Grand Ballroom West                   Session 23: Regenerative Rehabilitation: Integrating Mechanical Stimulation with TERM

Session Chairs: William Wagner and Kenton Gregory
SYIS Co–Chair: Samaneh Toufanian

Keynote Speakers:
1:00 PM – 1:10 PM                           Introduction

Karina Nakayama

1:10 PM – 1:30 PM                           Leveraging Mechanics to Direct Cartilage Regeneration

Riccardo Gottardi


1:30 PM – 1:50 PM                           Stem Cell and ECM Therapies for the Mitigation of Muscle Atrophy after Nerve Injury

Kacey Marra


1:50 PM – 2:10 PM                           Tissue Regeneration after Severe Extremity Injury Using Autologous Bone Marrow Mononuclear Cells

Kenton  Gregory

 

ORAL PRESENTATIONS:

 

2:10 PM – 2:20 PM                          87

Modulating Rehabilitation Intensity To Improve Functional Regeneration Of Severe Bone Fractures

  1. E. Nash1, J. Harrer1, K. Leguineche1, A. S. Lin1, B. Klosterhoff2, N. Willett1, R. E. Guldberg1;
    1Bioengineering, Phil and Penny Knight Campus for Accelerating Scientific Impact, Eugene, OR, 2McKinsey & Company, St. Louis, MO.

 

2:20 PM – 2:30 PM                          88

Slow Stretch And Cyclic Load Differentially Regulate Maturation In Tissue Engineered Ligament–to–bone Attachments

  1. E. Brown, J. L. Puetzer;
    Biomedical Engineering, Virginia Commonwealth University, Richmond, VA.

 

 

Osgoode Ballroom                         Session 24: Biomaterials for Women’s Health in Tissue Engineering  

Session Chairs: Jenny Robinson and Jon Grasman
SYIS Co–Chair: Chrisoula Chappell

Keynote Speakers:                        

1:00 PM – 1:30 PM                           Engineered Biomimetics to Promote Ovarian Folliculogenesis in Vitro and in Vivo

Ariella Shikanov

1:30 PM – 2:00 PM                           Biomaterials for Women’s Health in Tissue Engineering

Shelby White

 

ORAL PRESENTATIONS:


2:00 PM – 2:15 PM
                         89

Engineering High Throughput Screening Platforms Of Cervical Cancer

  1. Cadena, K. C. Fogg, 2016;
    Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR.

 

2:15 PM – 2:30 PM                          141

Sex Differences In Human Mesenchymal Stromal Cells And Meniscal Fibrochondrocytes Response To Fibrous Scaffold Properties And Estrogen Treatment

  1. E. Knewtson1, J. G. Gonzalez Flores2, A. R. Podgorny3, C. Zhong4, D. M. Pacicca5,6, J. L. Robinson1,2;

1Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, KS, 2Bioengineering Graduate Program, University of Kansas, Lawrence, KS, 3Center for Computational Biology, University of Kansas, Lawrence, KS, 4Department of Electrical Engineering and Computer Science, University of Kansas, Lawrence, KS, 5Department of Orthopaedic Surgery, Children’s Mercy Hospital, Kansas City, MO, 6School of Medicine, University of Missouri-Kansas City, Kansas City, MO.

2:30 PM – 3:00 PM                     Coffee Break in Exhibit Hall
Sheraton Hall A – F

2:30 PM – 3:00 PM                         TWIG Organizational Meetings
Grand Ballroom Centre                Imaging & Assessment
Grand Ballroom East                     Cardiovascular, Angiogenesis, Blood
Grand Ballroom West                   Scaffolds, Matrices and Biomaterials

Osgoode Ballroom                   Musculoskeletal

3:00 PM – 3:45 PM                     Jensen Tissue Engineering Award: Stephen Badylak, DVM, PhD, MD

Grand Ballroom Centre & West

 

3:45 PM – 4:15 PM                     WFIRM Awards: Jacqueline Larouche and Erik Jacques

Grand Ballroom Centre & West

 

4:15 PM – 4:30 PM                     Transitional Break

4:30 PM – 6:30 PM                     Exhibit Viewing / Reception / Poster Session 3
Sheraton Hall A – F

6:30 PM – 8:30 PM                     Evening Conference Reception
Grand Ballroom Foyer                 

7:15 PM – 7:45 PM                           SYIS Awards Announcements
Osgoode Ballroom                        
Sponsored by Wiley

8:30 PM – 9:30 PM                     2024 Planning Team Meeting
Simcoe/Dufferin, 2nd Floor

7:00 AM – 12:00 PM                        Registration

Vide Foyer

 

8:00 AM – 9:30 AM                     Scientific Concurrent Sessions 7

Grand Ballroom Centre                Session 25: Bioactive Biomaterials for Soft Tissue Engineering

Session Chairs: Evelyn Yim and Catherine Le Visage
SYIS Co–Chair: Raja Rajeshwari Thada

Keynote Speakers:
8:00 AM – 8:20 AM                          TBD

Barbara Chan

8:20 AM – 8:40 AM                          Nanostructured Synthetic Hydrogels for Promoting Tissue Regeneration

Todd Hoare

8:40 AM – 9:00 AM                          Regenerative Engineering for Joint Injury and Osteoarthritis

Blanka Sharma


RAPID FIRE PRESENTATIONS:

9:00 AM – 9:05 AM                         91

Jagged1 Immobilized Viscoelastic Hydrogel Induces Bile Duct Organoid Formation

  1. Rizwan1, C. Ling2, M. Ogawa3, S. Ogawa3, G. Keller3, M. S. Shoichet2;
    1Biomedical Engg, Michigan Technological University, Houghton, MI, 2University of Toronto, Toronto, ON, CANADA, 3University Health Network, Toronto, ON, CANADA.

 

9:05 AM – 9:10 AM                         92

Injectable, Pore–forming, Perfusable Double–network Hydrogels Resilient To Extreme Biomechanical Stimulations

  1. Bao, S. Taheri, J. Li, L. Mongeau;
    McGill University, Montreal, QC, CANADA.

 

9:10 AM – 9:15 AM                         93

Biofunctional Peptide–based 3D Matrices For Advanced Tissue Engineering

  1. Ross;
    University of Ottawa Heart Institute, Ottawa, ON, CANADA.

 

9:15 AM – 9:20 AM                         94

Extracellular Matrix Hydrogel Platform For The Interrogation Of The Role Of Inflammation In T Cell Migration In Type 1 Diabetes

  1. M. Samojlik1, S. N. Patel1, Y. Li2, A. T. Fernandez1, T. M. Brusko2, C. E. Mathews2, E. A. Phelps1, C. L. Stabler1;
    1Biomedical Engineering, University of Florida, Gainesville, FL, 2Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL.

 

9:20 AM – 9:25 AM                         95

RhCollagen – The Ideal Building Block For 3D Printed And Injectable Scaffolds For Regenerative Medicine

  1. Rubinchik–Stern, R. Mashiach, S. Louzoun–Zada, N. Orr;
    R&D, CollPlant LTD, Rehovot, ISRAEL.

 

9:25 AM – 9:30 AM                       142

Biocompatible Peg Diacrylate Hydrogel Nanocomposite Emulsion Scale Down For SiRNA Drug Delivery Platforms For Adipocyte Beiging

  1. Negru1, J. Park1, F. Teymour2, G. Papavasiliou1, M. Vaicik1;

1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, 2Chemical Engineering, Illinois Institute of Technology, Chicago, IL.

 

 

Grand Ballroom East                     Session 26: Non–invasive Imaging and Analysis of Engineered Tissues

Session Chairs: Marcella Vaicik and Eric Brey
SYIS Co–Chair: Heta Lad

Keynote Speaker:                           

8:00 AM – 8:30 AM                          In Vitro and In Vivo Oxygen Imaging Assessment of Islet Transplantation Devices

Mrignayani Kotecha

 

ORAL PRESENTATIONS:

 

8:30 AM – 8:50 AM                         97

High–frequency Ultrasound To Assess The Acoustic Properties Of Cell–laden Hydrogels In Vitro

  1. A. Sebastian1,2, E. M. Strohm3, E. Chérin4, B. Mirani1,2, Z. Mirzaei1,2, C. Démoré4, M. C. Kolios3, C. A. Simmons1,2;
    1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Translational Biology and Engineering Program, Ted Rogers Center for Heart Research, Toronto, ON, CANADA, 3Department of Physics, Ryerson University, Toronto, ON, CANADA, 4Sunnybrook Research Institute, Toronto, ON, CANADA.

 

8:50 AM – 9:10 AM                         98

CT–visible Microspheres Enable In Vivo Tracking Of Biomaterial Distribution After Ultrasound–guided Intramyocardial Injection

  1. Bettini1, P. Patrick2, R. M. Day1, D. J. Stuckey2;
    1Centre for Precision Healthcare, University College London, London, UNITED KINGDOM, 2Centre for Advanced Biomedical Imaging, University College London, London, UNITED KINGDOM.

 

9:10 AM – 9:30 AM                         99

Comprehensive Toolbox For Functional Analysis Of Ipsc Derived Cardiomyocytes

  1. E. Cortes1,2, B. Toma3, Y. Wu2, A. Saraf3,4,5;
    1Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2Developmental Biology, Children’s Hospital of Pittsburgh, Pittsburgh, PA, 3Department of Medicine, Heart and Vascular Institute, Pittsburgh, PA, 4Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, 5Department of Medicine, Aging Institute, Pittsburgh, PA.

 

 

Grand Ballroom West                   Session 27: Cell–based Approaches to Cardiac Regeneration & Repair

Session Chairs: Craig Simmons and Stephanie Protze
SYIS Co–Chair: Saif Rjaibi

Keynote Speaker:
8:00 AM – 8:30 AM                          Cell Therapies for the Cardiac Conduction System

Stephanie Protze

 

ORAL PRESENTATIONS:

8:30 AM – 8:45 AM                         100

Functional Maturity Of Pluripotent Stem Cell–Derived Cardiomyocytes Is Advanced With A Novel Maturation Medium Formulation

  1. Callaghan1, L. Durland1, W. Chen2, U. Kuzmanov3, M. Z. Miranda1, Z. Mirzaei1, R. Ireland1, M. M. Kim1, J. Audet1, P. Santerre1, A. Gramolini3, S. Mital4, J. Ellis5, P. Backx2, C. Simmons1;
    1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Department of Biology, York University, Toronto, ON, CANADA, 3Department of Physiology, University of Toronto, Toronto, ON, CANADA, 4The Hospital for Sick Children, Toronto, ON, CANADA, 5Department of Molecular Genetics, University of Toronto, Toronto, ON, CANADA.

 

8:45 AM – 9:00 AM                         101

Fibrin, Bone Marrow Cells And Macrophages Interactively Modulate Cardiomyoblast Fate: An In Vitro Study

  1. Borrego1, A. Frobert1, s. Cook2, M. N. Giraud1;
    1Unifr, Fribourg, SWITZERLAND, 2HFR, Fribourg, SWITZERLAND.

 

9:00 AM – 9:15 AM                         102

Harnessing The Potential Of Immune Cells To Promote Cardiac Repair Following Myocardial Infarction

  1. K. Alshoubaki, B. Nayer, E. Salimova, Y. Lu, J. Tan, G. del Monte Nieto, M. Martino;
    Australian Regenerative Medicine Institute, Monash University, Clayton, AUSTRALIA.

 

9:15 AM – 9:30 AM                         103

Proteomic Profiling Of Cardiac Tissue After Cell–based Therapies

  1. Makkaoui1, V. Prasad1, H. Toren1, T. Carmona1, K. Li1, J. Maxwell2;
    1Emory University School of Medicine, Atlanta, GA, 2Wake Forest Institute for Regenerative Medicine, Winston–Salem, NC.

 

 

Osgoode Ballroom                         Session 28: Engineering Microvasculature for Tissue Regeneration
Sponsored By: MCS / The Microcirculatory Society, Inc.

Session Chairs: Feng Zhao and Ngan Huang
SYIS Co–Chair: Alexane Thibodeau

Keynote Speakers:
8:00 AM – 8:30 AM                          Engineering Anastomotic and Structured Microvessels for Soft Tissue Regeneration

Feng Zhao

8:30 AM – 9:00 AM                          Stem Cells, Diabetes, and Vascular Regeneration

Sara Nunes Vasconcelos

ORAL PRESENTATIONS:

9:00 AM – 9:10 AM                         104

Vasculature–on–a–chip Platform With Innate Immunity Enables Identification Of Angiopoietin–1 Derived Peptide As A Therapeutic For Sars–cov–2 Induced Inflammation

  1. Lu;
    University of Toronto, Toronto, ON, CANADA.

 

9:10 AM – 9:20 AM                         105

Physiologically Engineered In–vitro Model Of Lymphatic Vessel Growth & Function Using HA–Hydrogels

  1. Alderfer, F. Fan, D. Hanjaya–Putra;
    University of Notre Dame, Notre Dame, IN.

 

9:20 AM – 9:30 AM                         106

Vascularized Heart–On–A–Chip For Drug Testing And Disease Modeling

  1. Zhao1, M. Radisic1, G. Vunjak–Novakovic2;
    1University of Toronto, Torono, ON, CANADA, 2Columbia University, NYC, NY.

 

9:30 AM – 9:45 AM                     Coffee Break
Grand Ballroom Foyer

9:45 AM – 11:15 AM                   Scientific Concurrent Sessions 8

Grand Ballroom Centre                Session 29: 3D Tissue–Engineered Cancer/Disease Modeling and Organoids Part 2

Session Chairs: Eliza Fong and Rui Reis
SYIS Co–Chair: Ahmad Galuta

Keynote Speaker:
9:45 AM – 10:05 AM                       Engineering Tumor Explants with Biomaterials

Eliza Fong


ORAL PRESENTATIONS:

10:05 AM – 10:20 AM                    107

Investigating The Effects Of Microenvironmental Features On Tumor Cell Heterogeneity In Pancreatic Cancer Using A 3D In Vitro Model

  1. Landon–Brace1, J. L. Cadavid2, S. Latour1, I. L. Co1, E. Bugbee1, A. P. McGuigan2;
    1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Chemical Engineering & Applied Chemistry, University of Toronto, Toronto, ON, CANADA.

 

10:20 AM – 10:35 AM                    108

Probing The Interaction Of Macrophages And Tumour Cells In The Hypoxic Pancreatic Cancer Microenvironment Using A 3D In Vitro Model

  1. L. Co1, N. Landon–Brace1, S. Lamorte2, A. Fomina1, J. L. Cadavid1,3, Z. Xia3, T. L. McGaha2,4, A. P. McGuigan1;
    1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, CANADA, 2Princess Margaret Cancer Centre, University Health Network, Toronto, ON, CANADA, 3Dept of Chemical Engineering and Applied Sciences, University of Toronto, Toronto, ON, CANADA, 4Dept of Immunology, University of Toronto, Toronto, ON, CANADA.

 

10:35 AM – 10:50 AM                    109

Microbiome Metabolites Alter Immune Checkpoint Blockade Efficacy In Novel Immunoreactive Cancer Organoid Model

  1. N. Shelkey, S. Soker;
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston–Salem, NC.

 

10:50 AM – 11:05 AM                        143

Colorectal Cancer Secretome Promotes Fibroblast Activation And Suppresses Pericyte Function In 3d Premetastatic Niche Model

  1. Nairon1, A. Skardal2,1;

1Department of Biomedical Engineering, The Ohio State University, Columbus, OH, 2The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH.

 

RAPID FIRE PRESENTATIONS:

11:05 AM – 11:10 AM                    111

Modular Hydrogels Enable Ex Vivo Prostate Cancer Xenograft Culture Alongside Stromal Fibroblasts In A High–throughput Microfluidic Plate

  1. Bonteanu1, D. Iyer2, P. Shepherd3, R. Kittles4, N. M. Navone3, K. Bircsak2, D. Harrington5;
    1Department of Bioengineering, Rice University, Houston, TX, 2MIMETAS US Inc, Gaithersburg, MD, 3Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 4City of Hope, Duarte, CA, 5Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX.

 

11:10 AM – 11:15 AM                    112

IFlowplate– A Customized 384–Well Plate For The Culture Of Perfusable And Vascularized Colon Organoids

  1. Rajasekar, D. S. Lin, L. Abdul, A. Liu, A. Sotra, F. Zhang, B. Zhang;
    Chemical Engineering, McMaster University, Hamilton, ON, CANADA.

 

 

Grand Ballroom East                     Session 30: ECM Technologies in Musculoskeletal Repair

Session Chairs: Michael McClure and Lisa Larkin
SYIS Co–Chair: Vimala Devi Mohan

Keynote Speaker:                           

9:45 AM – 10:15 AM                       Impacts of Aging Upon the Host Response to Extracellular Matrix–Based Biomaterials

Bryan Brown


ORAL PRESENTATIONS:

10:15 AM – 10:30 AM                    113

3d Printed Biphasic Inductive PCL Scaffolds For Treating Large Osteochondral Defects In Porcine Model

  1. W. Whitlock1, J. Hall2, J. Lin2, S. Murab3;
    1Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2University of Cincinnati, Cincinnati, OH, 3Indian Institute of Technology Mandi, Mandi HP–175075, INDIA.

 

10:30 AM – 10:45 AM                    114

Development Of Photocrosslinkable Colloidal Composite Decellularized Cartilage Extracellular Matrix Bioinks

  1. Hogan1,2, M. Perez1, A. G. Mikos1;
    1Bioengineering, Rice University, Houston, TX, 2Medical Scientist Training Program, Baylor College of Medicine, Houston, TX.

 

10:45 AM – 11:00 AM                   144

Development Of Antibacterial Hydrogels Based On Hyaluronic Acid And ɛ-poly-l-lysine For Bone Tissue Regeneration

  1. Salma-Ancane1, A. Sceglovs1, I. Kreicberga1, A. Ramata-Stunda2, V. Nikolajeva2, D. Loca1;

1Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Riga Technical University, Riga, LATVIA, 2Department of Microbiology and Biotechnology, Faculty of Biology, University of Latvia, Riga, LATVIA.

 

11:00 AM – 11:15 AM                    116

Engineering Pre–vascularized Bone Tissue Through Simulating Endochondral Ossification

  1. Lin, X. Zhang;
    University of Pittsburgh School of Medicine, Pittsburgh, PA.

 

 

Grand Ballroom West                   Session 31: Regenerative Medicine Applications to Organ Transplantation Medicine

Session Chairs: Giuseppe Orlando and Kim Solez
SYIS Co–Chair: Tania Sultana

Keynote Speakers:
9:45 AM – 10:15 AM                       Developing Targeted Cell Therapies for Liver Disease

Shinichiro Ogawa

10:15 AM – 10:45 AM                     The Potential of Regenerating Ischemically Damaged Renal Allografts

Lauren Brasile

ORAL PRESENTATIONS:

10:45 AM – 11:00 AM                    117

An Open Thin Film Microwell Beta Cell Delivery Device For Type 1 Diabetes

  1. de Vries1, D. de Bont1, R. Goutchtat2, E. J. de Koning3, T. Hubert4, F. Pattou5, A. A. van Apeldoorn1;
    1MERLN institute for technology–inspired regenerative medicine, Maastricht University, Maastricht, NETHERLANDS, 2Université de Lille, Lille, FRANCE, 3Department of Endocrinology, Leiden University Medical Center, Leiden, NETHERLANDS, 4Faculté de Médecine de Lille Pôle Recherche, Université de Lille, Maastricht, NETHERLANDS, 5Department of General and Endocrine Surgery, University Hospital Lille, Lille, FRANCE.

 

11:00 AM – 11:15 AM                    118

3d Bioprinted Kidney–derived Bioink Constructs For Renal Tissue Regeneration

  1. Lee, G. Carreno Galeano, J. Yoo, A. Atala;
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston–Salem, NC.

Osgoode Ballroom                         Session 32: Biometal Mediated Tissue Regeneration

Session Chairs: Kelvin Yeung and Donghui Zhu
SYIS Co–Chair: Lorena Duarte

Keynote Speakers:
9:45 AM – 10:15 AM                       Additive Manufactured Biodegradable Metal Scaffolds for Bone Tissue Engineering

Donghui Zhu

 

10:15 AM – 10:45 AM                     Osteoimmunomodulated Bone Healing By Sequential Intervention Of Divalent Cation

Kelvin Yeung

ORAL PRESENTAIONS:

10:45 AM – 11:00 AM                    119

3d Printing Of LEGO®–inspired Titanium Scaffold For Patient–specific Regenerative Medicine

  1. S. Lee1, X. Du1, T. Smit1, D. Seiler2, M. de Wild2, S. J. Ferguson1;
    1Institute for Biomechanics, ETH Zurich, Zurich, SWITZERLAND, 2Institute for Medical and Analytical Technologies, University of Applied Sciences Northwestern Switzerland, Muttenz, SWITZERLAND.

 

11:00 AM – 11:15 AM                    120

Osteoimmunomodulated Bone Healing By Sequential Intervention Of Divalent Cation

  1. Yeung, W. Qiao;
    Orthopaedics and Traumatology, The University of Hong Kong, Pokfulam, HONG KONG.

11:15 AM – 11:30 AM                 Closing Ceremony
Grand Ballroom Centre

11:30 AM – 1:00 PM                   Lunch (on own)

1:00 PM – 2:30 PM                    SYIS Career Panel Discussion
Osgoode Ballroom                        
Sponsored by: Medicine by Design (MbD), and Burroughs Wellcome Fund

2:30 PM – 4:00 PM                     SYIS Lab Tours at JLABS and CRAFT
Pre–registration required. Meet in the Osgoode Ballroom at 2:30 pm